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A blog about political change, among other things

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Israeli scientists come up with something that sounds very promising

The New Neo Posted on April 10, 2020 by neoApril 10, 2020

It’s only been tested on a very small number of COVID patients. But those people were all in exceedingly bad shape, and they all survived.

From the Jerusalem Post:

The patients were treated at three different Israeli medical centers for one week under the country’s compassionate use program and were suffering from acute respiratory failure and inflammatory complications associated with COVID-19. Four of the patients also demonstrated failure of other organ systems, including cardiovascular and kidney failure.

Not only have all the patients survived, according to Pluristem, but four of them showed improvement in respiratory parameters and three of them are in the advanced stages of weaning from ventilators. Moreover, two of the patients with preexisting medical conditions are showing clinical recovery in addition to the respiratory improvement.

It’s only a few people, but those are dramatic results because some of those people would ordinarily be expected to die.

Here’s a description of the treatment:

According to Pluristem, the PLX cells are “allogeneic mesenchymal-like cells that have immunomodulatory properties.” Translated, that means that they harness our own immune system’s regulatory T cells and M2 macrophages to prevent overactivation of the immune system. This helps us avoid the symptoms of pneumonia and pneumonitis from becoming fatal.

More details here:

PLX cells are available off-the-shelf and once commercialized, can be manufactured in large scale quantities, offering a key advantage in addressing a global pandemic…

For Pluristem’s compassionate use program, all the seven patients approved for treatment with PLX cells exhibited, prior to treatment, respiratory failure due to ARDS, which is a major cause of mortality and required mechanical ventilation in an ICU. Four of the patients also demonstrated failure of other organ systems, including cardiovascular and kidney failure, indicating critical disease and poor prognosis. Six patients completed one week follow up, while the seventh patient was treated on April 5 2020. Preliminary data following treatment with PLX cells demonstrated a 100% survival rate. Four out of the six (66%) patients who completed one week follow up demonstrated improvement in respiratory parameters. Three out of the six (50%) patients who completed one week follow up are in advanced stages of weaning from ventilators. Pluristem now plans to apply for initiation of a multinational regulated clinical trial program for the potential use of PLX cells in the treatment of patients suffering from complications associated with COVID-19.

A study needs to be fast-tracked in the US.

Posted in Health, Israel/Palestine | Tagged COVID-19 | 4 Replies

California has started antibody testing

The New Neo Posted on April 10, 2020 by neoApril 10, 2020

There’s a reason California is a good choice for such a test:

The team tested 3,200 people at three Bay Area locations on Saturday using an antibody test for COVID-19 and expect to release results in the coming weeks. The data could help to prove another theory, one that believes COVID-19 arrived undetected in California much earlier than previously thought.

As of Tuesday, the state had 374 reported COVID-19 fatalities in a state of 40 million people, compared to New York which has seen 14 times as many fatalities and has a population half that of California. Social distancing could be playing a role but New York’s stay-at-home order went into effect on March 22, three days after California implemented its order.

“Something is going on that we haven’t quite found out yet,” said [Victor Davis] Hanson.

Hanson said he thinks it is possible COVID-19 has been spreading among Californians since the fall when doctors reported an early flu season in the state. During that same time, travel between China and America was unfettered. Some of those visitors even arriving on direct flights from Wuhan, the epicenter of the coronavirus outbreak in China.

It makes a certain amount of sense, particularly if there really was an early flu season in California. However, it would also have to have been a particularly lethal flu season, and I would think that would have gotten more attention.

But the tests will tell the tale. I’m eager to hear the results. It’s hard to be patient with so much on the line.

Posted in Health, Uncategorized | Tagged COVID-19 | 17 Replies

Good news on Boris Johnson

The New Neo Posted on April 9, 2020 by neoApril 9, 2020

He’s been moved out of intensive care:

“The Prime Minister has been moved this evening from intensive care back to the ward, where he will receive close monitoring during the early phase of his recovery,” a spokesman said on Thursday. “He is in extremely good spirits.”

I bet he is.

He has been sitting up in bed but could still be out of action for at least a month, according to reports.

For someone like Johnson, backing off from work will be hard. But he needs to be careful not to push himself.

Posted in Health | Tagged Boris Johnson, COVID-19 | 26 Replies

Part I: is this “just a bad flu”?

The New Neo Posted on April 9, 2020 by neoApril 9, 2020

I see it over and over: assertions that COVID-19 is just “a bad flu,” and accusations that those who say that are wrong, wrong, wrong.

Both statements annoy me – but then, maybe I’m just getting testy from being cooped up.

Or maybe I’m not just being testy, because what annoys me is that the phrases “the flu” or even “a bad flu” are rarely defined. They seem to have become protean terms that people use as they see fit.

So first I’d like to give some definitions. For “flu”:

There are two main types of influenza (flu) virus: Types A and B. The influenza A and B viruses that routinely spread in people (human influenza viruses) are responsible for seasonal flu epidemics each year.

Influenza viruses can and do change quite regularly, and the people who make vaccines try (and sometimes fail) to keep up with those changes. But the viruses remain one of those two types.

Note also that word “seasonal.” There is a flu season, and although it drifts around somewhat and varies somewhat in length, it tends to be from later in the fall to sometime in the spring.

This is part of life and happens every year. But some of these seasonal flu seasons are worse than others, so there’s a lot of variation in how many people get sick, how sick they get, how many die, and the age distribution of all of the above.

COVID-19 is a different type of virus, a coronavirus rather than a flu virus. However, just to complicate matters, this particular coronavirus causes symptoms that are very very much like the flu. But we don’t know how seasonal it is. And still another important difference is that we already have vaccines for the flu, and so it’s not so very hard and doesn’t take so very long to transform those vaccines into one for a new flu strain.

That’s not true of coronaviruses. We started to develop a vaccine for the previous one known as SARS (although COVID-19’s official name is “SARS-CoV-2,” just to complicate matters). But the process was never finished because the disease ended up being far more localized than originally thought and therefore the money was never spent to fully develop a vaccine that was considered to be unnecessary. That SARS vaccine work might be helpful in developing a vaccine against COVID, but it’s nothing like the head start we ordinarily have in developing vaccines for new types of flu.

But sometimes a flu becomes a far greater killer than it usually is even in a “bad” year. Sometimes the flu becomes a far more vicious killer around the world. These flu pandemics also vary in deadliness, although they all are nasty. In the 20th century we had three: 1918, 1957, and 1968.

You probably know that 1918 was the worst of all. I’ve written about it before:

How many people died worldwide? Estimates vary, but the most conservative state that the death toll was 25 million. Oher estimates go much higher, up to 70 million or even 100 million.

That’s worldwide, in a time when the population was much smaller than today. The US was by no means the hardest hit, but it’s estimated that we lost about 675,000 Americans back when the US population was somewhat less than a third what is today – so today’s equivalent US death toll would be approximately two million.

That was devastating, and it also was “the flu.” What’s more, that illness tended to work in a way that was somewhat strange for flu: it killed the young and old, which is typical, but it also killed a far greater proportion of young adults in the prime of life.

So there’s no “just” to “just the flu,” unless you specify something like “regular seasonal flu rather than pandemics” – which is a mouthful.

But even regular seasonal flu can be very very bad. We accept it for various reasons, though. One is that we’re used to it. Another is that the media reports on it at times but doesn’t often highlight or spotlight it. Another is that it tends to kill the very old (although COVID does the same in that regard, and yet is very much in the new). What’s more, flu deaths are mostly estimated. It’s a little-known fact (at least, I didn’t know it till recently), but patients – even those who die – are not tested for flu that often.

So all these things have combined to make the terms “flu” and even “seasonal flu” take on an aspect far more benign than they sometimes deserve.

Let’s take an example from the “bad” flu year of 2017-2018. That wasn’t so very long ago, right? So we all should remember, correct? But we don’t; I certainly didn’t, until COVID came along and I started looking this sort of thing up (the article is from early February 2018):

The amount of influenza ravaging the U.S. this year rivals levels normally seen when an altogether new virus emerges, decimating a vulnerable population that hasn’t had a chance to develop any defenses.

It’s an unexpected phenomenon that public health experts are still trying to decode.

And yet it flew under the radar for most of us, although I assume that the CDC, doctors, and hospitals were paying close attention:

The primary type of influenza this year hasn’t changed enough from previous seasons to be considered a novel strain, Schuchat said. The agency’s virologists are studying it to determine if there are any other explanations for why it’s been so hard-hitting…

Deaths from influenza and pneumonia, which are closely tied to each other in the winter months, were responsible for 1 of every 10 deaths last week, and that’s likely to rise, Schuchat said in a conference call Friday. There were 40,414 deaths in the U.S. during the third week of 2018, the most recent data available, and 4,064 were from pneumonia or influenza, according to the CDC data. The number for that week is expected to rise more reports are sent to the agency.

It gets worse. The death toll in future weeks is expected to grow even higher because flu activity is still rising…

That was written on February 10. I don’t have weekly figures for later in the season, but I’m going to assume they went up, although I doubt they ever came to rival what we’ve seen lately with COVID-19. Of course, none of these are exact figures. The flu deaths in 2017-2018 were estimates. And the deaths attributed to COVID-19 may be over- or under-reported as well (are all people with COVID who die being labeled COVID deaths no matter what they may be dying from, and/or are home deaths from COVID not being properly listed as caused by the disease?). But the figures are all we have to go on.

Here’s the CDC report on that 2017-2018 season. You can see the death rate estimates that year per 100,000 people were as follows: for ages 0-4 it was .4 (or 115 total), for ages 5-17 it was 1 (or 528 total), for ages 18-49 it was 2 (or 2803 total), for ages 50-64 it was 10.6 (or 6751 total), for ages over 65 it was 100 (or 50,903 total).

Of course, we didn’t have social distancing edicts back then. And I’m not saying that social distancing is a bad idea now, because I do think that without them, COVID would be killing a lot more people. It’s already killing plenty, and it certainly seems that it’s at least going to be equal to a “bad” flu year even with all these draconian rules in place. But the big (and so far unanswerable) questions are: at what cost? How many more deaths would there have been without the rules that are crippling the economy and causing resultant hardship?

[NOTE: This is Part I of a projected two-or-more-part series on the topic of COVID and flu. My plan is to cover the following: the 1957-1958 “Asian” flu pandemic, the 1968-1969 “Hong Kong” flu pandemic, and the “swine” flu H1N1 pandemic of 2009-2010.]

Posted in Health, History | Tagged COVID-19 | 97 Replies

A synopsis of recent press briefings

The New Neo Posted on April 9, 2020 by neoApril 9, 2020

[Hat tip: Scott Johnson at Powerline]

Funny, and sadly true:

Posted in Press, Trump | Tagged COVID-19 | 10 Replies

Treatments that show promise…

The New Neo Posted on April 9, 2020 by neoApril 9, 2020

…don’t always pan out.

But this definitely shows promise for those COVID patients who are in dire straits:

Six critically ill coronavirus patients in Israel who are considered high-risk for mortality have been treated with Pluristem’s placenta-based cell-therapy product and survived, according to preliminary data provided by the Haifa-based company.

The patients were treated at three different Israeli medical centers for one week under the country’s compassionate use program and were suffering from acute respiratory failure and inflammatory complications associated with COVID-19. Four of the patients also demonstrated failure of other organ systems, including cardiovascular and kidney failure.

[Hat tip: commenter “sdferr.”]

Posted in Health, Israel/Palestine, Science | Tagged COVID-19 | 2 Replies

“Just anecdotal”…

The New Neo Posted on April 8, 2020 by neoApril 8, 2020

…but powerful nevertheless:

However, from everything I’ve heard and read, the medication combination is probably most effective if given before things really go south. If a person is already on a ventilator, for example, the amount of lung damage that has already taken place may often make it very difficult for any drug to do its work.

At a certain point, “anecdotal” evidence – in a situation in which we have few other tools to fight a disease that kills too many people – becomes very compelling. To not treat, and to wait for large-scale controlled studies, considering that the drug has already been approved for 60 years and is generally considered extremely safe, is hard to justify. Not only that, but although controlled experiments are necessary to really understand whether it’s helping at all and to what degree, is it ethical to have untreated controls in a situation like this?

It’s a very real dilemma.

When the left speaks so forcibly against Trump’s mentioning that the drug has shown promise, I think they have two motives. The first is obvious: anything Trump says might be good is by definition bad. The second is a little more subtle: the left positions itself as the science-based group and has put out a relentless message that Trump and his supporters are anti-science. That message has been received by liberal Democrats; I have heard it many times from friends and family, and increasingly in the past week or two. Controlled studies are definitely science-based, so that’s another way in which the left wants to position itself as champions of science as opposed to charlatan Trump.

Now of course, Trump never said not to do controlled trials. It doesn’t have to be either/or. But the left needs to pretend that’s the situation. To do so, though, they have to work against the emotional appeal of stories such as Dr. Siegel’s, as well as the tale told by Michigan state Rep. Karen Whitsett.

However, if this drug combination does end up being proven effective against COVID-19, I wouldn’t be surprised if the MSM and the Democrats pretend they never criticized it, and that in fact Trump was too slow to recommend it and therefore has blood on his hands.

Posted in Health, Politics, Science | 62 Replies

“How the Wuhan Virus Will Change the World Order”

The New Neo Posted on April 8, 2020 by neoApril 8, 2020

Recommended.

Here’s an excerpt:

We don’t know exactly when Beijing officials learned about Wuhan’s troubles, but it was probably early- to mid-December. They didn’t learn earlier because local officials know the surest way to lose your position is to give your boss bad news. So they withheld it. When Beijing did learn, it intensified the crackdown and enforced stay-at-home orders. The CCP then delayed telling the world. It also refused multiple offers of medical help. Some say they refused out of national pride. Perhaps, but they also feared what outside professionals might find.

Meanwhile, Beijing continued to send official delegations around the world, including one to the White House and a huge one to Davos, long after it knew the dangers. Far worse, it allowed more than 750,000 people to fly to the U.S. in December, January, and February, again, after CCP officials knew the virus was highly contagious and spreading quickly. Where did they fly, besides America? Well, Italy, for starters. Wherever Chinese people like to vacation. And wherever China has economic and strategic interests. The first global hot spots show exactly where they landed. The contagion spread its deadly tentacles from there.

Why didn’t the World Health Organization sound the alarm? For two reasons: It had bad information (from China) and it never confronts Beijing, which effectively controls the organization, even though it is a far-smaller donor than the U.S. The CCP has a crucial say over who holds senior positions at the WHO, and it shows. That’s why a top official there actually hung up — on camera — when a reporter had the temerity to ask about Taiwan’s success in combating the virus. That’s why, in mid-January, the WHO was still telling the world exactly what China told them: The novel-coronavirus did not spread by human-to-human contact. The WHO probably believed that, but by then Beijing must have known it was false. The WHO also opposed President Trump’s decision to block travel from China, the most important early step to limit the pandemic in America.

The WHO’s fecklessness mattered. According to Dr. Deborah Birx, reports from the WHO and China led U.S. health officials to think, wrongly, that this problem was much like SARS, serious but manageable. It was far worse than that and far more contagious. We should have been told.

Much much more at the link.

Posted in Health, Politics | Tagged China, COVID-19 | 9 Replies

Bret Easton Ellis: political changer

The New Neo Posted on April 8, 2020 by neoApril 8, 2020

Here’s another changer – a recent one, author Bret Easton Ellis – telling his story. I was alerted to this by a helpful reader:

Posted in Leaving the circle: political apostasy, Political changers | 22 Replies

It seems paradoxical to enforce social distancing rules…

The New Neo Posted on April 8, 2020 by neoApril 8, 2020

…by trying to strangle someone:

A doctor in Louisville, Ky., was arrested and charged with strangulation after a fight ensued with teens over not following social distancing measures amid the coronavirus outbreak.

The Louisville Metro Police Department (LMPD) was alerted Monday to a video showing a group of teens being cursed at by a man while he shoved them and put his hands around the neck of a girl, according to local CBS affiliate WLKY.

I assume the strangulation wasn’t successful, or the charges would have been somewhat different.

The paradox here is a double one. One element is that this is a doctor: “first, do no harm.” Another is that in order to strangle someone – unless your arms are very long and you are wearing protective gloves – you ordinarily have to get up close and personal.

But it illustrates something I’ve noticed, which is the spark of anger people often feel nowadays when someone comes too close or otherwise violates the rules. Once things go “back to normal,” I wonder if some of this feeling of danger when strangers are near will linger, and whether the sense of a safe amount of personal space will have permanently changed.

Posted in Health, Violence | Tagged COVID-19 | 12 Replies

Bernie does what he does best: drops out of the race

The New Neo Posted on April 8, 2020 by neoApril 8, 2020

Remember that old Timothy Leary prescription – “turn on, tune in, drop out”? I bet Bernie does.

Today he announced he’s dropping out of the race, although he remains on the ballot for the rest of the primaries.

“I wish I could give you better news, but I think you know the truth. And that is that we are now some 300 delegates behind Vice President Biden and the path to victory is virtually impossible,” Sanders said.“I have concluded that this battle for the Democratic nomination will not be successful, and so today I am announcing the suspension of my campaign.”

He said that the ongoing coronavirus pandemic had hastened his decision to suspend his campaign, saying that continuing his presidential bid would only distract from efforts to combat the outbreak and damage it has done to the U.S. economy.

“I cannot in good conscience continue to mount a campaign that cannot win and which would interfere with the important work required of all of us in this difficult hour,” he said.

The most important work of all, of course, is to unite in criticizing Trump’s handling of the health crisis.

Truth is, Bernie was the front runner until the DNC became alarmed and decided to marshall its considerable forces – including the MSM – to do Sanders in.

So now they are left with a lot of angry Sanders supporters, Joe Biden, and a Possible Player to be Named Later.

Trump wasted no time:

Bernie Sanders is OUT! Thank you to Elizabeth Warren. If not for her, Bernie would have won almost every state on Super Tuesday! This ended just like the Democrats & the DNC wanted, same as the Crooked Hillary fiasco. The Bernie people should come to the Republican Party, TRADE!

— Donald J. Trump (@realDonaldTrump) April 8, 2020

This has been the strangest campaign season in my memory. And it’s not over yet. Now that the DNC has stopped Bernie, will they manage to stop Biden, which is a bit more complex procedurally but could be done? And if not, will they manage to drag him over the finish line somehow? Will the long push to get the public to hate and reject Trump be successful, even with Biden nominally at the helm? And if not Biden, than who?

What a mess.

Posted in Election 2020 | Tagged Bernie Sanders | 12 Replies

RIP John Prine

The New Neo Posted on April 7, 2020 by neoApril 7, 2020

I’ve loved this song for a long, long time:

This article says he died of COVID-19 complications. That last word is a bit confusing. He had a history of successfully treated lung cancer from 2013, so it’s not clear how that factored into it. Prine had been hospitalized with COVID-19 since March 26 and on a ventilator since March 28.

Posted in Uncategorized | 19 Replies

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