We could use some encouraging news, and I think this qualifies:
The researchers are calling their experimental vaccine ChAdOx1 nCoV-19 (AZD1222). It combines genetic material from the coronavirus with a modified adenovirus that is known to cause infections in chimpanzees. The phase one trial had more than 1,000 participants in people ages 18 to 55.
The researchers said the vaccine produced antibodies and killer T-cells to combat the infection that lasted at least two months. Neutralizing antibodies, which scientists believe is important to gain protection against the virus, were detected in participants. The T-cell response did not increase with a second dose of the vaccine, they said, which is consistent with other vaccines of this kind.
“The immune system has two ways of finding and attacking pathogens — antibody and T cell responses,” Oxford professor Andrew Pollard said in a release. “This vaccine is intended to induce both…”
For quite a few months, I’ve noticed a lot of skepticism on both left and right about the possibility of developing an effective vaccine. And I mean a lot of skepticism. The criticisms range from general distrust of anything medical – the “evil big pharma” approach – to specific objections that we’ve never been able to develop a vaccine for a coronavirus.
I’m not in either camp. I actually think that for the most part vaccines work and that the companies who develop them are trying very hard to make them safe, and that although they don’t always succeed, they usually do. The potential problem I see with the COVID vaccine development might be inordinate speed, but I also understand why that’s happening, as well.
As for the argument about never having had a coronavirus vaccine before, I don’t see that as a stumbling block either. Here’s the way it’s sometimes stated (the quote’s from about two months ago):
According to [Dr. Bhattacharya’s] assessment, a vaccine is an open-ended question. None of the other coronaviruses that infect humans have one and there is no guarantee this one will.
Technically true but also misleading. Coronaviruses have mainly caused two types of illness. The first is akin to the common cold (also caused by rhinoviruses). Vaccine development is expensive and laborious, and to develop one for colds has never been cost-effective because there are just way too many strains of virus and types of virus involved, and the illness itself is not dangerous. The second type of illness caused by coronavirus in the past has been of the SARS/MERS variety. Scientists were in the process of developing vaccines, but before they got to the final states the viruses petered out and it was no longer cost-effective (or even possible, considering how uncommon the viruses had become in the population) to continue with the development of the vaccines.
That doesn’t mean we’ll have a COVID vaccine soon; there may be stumbling blocks ahead. But it does mean there’s no reason to think we won’t have one – unless the illness becomes so infrequent that testing can’t effectively go on, or wouldn’t be worth the expense. I don’t think I’d weep if that were to happen.
