One can hope.
Regular readers of this blog may recall that I’ve written several times about sepsis. It’s a topic I really knew nothing about until I lost a loved one to it, and then I lost another. They both had other illnesses—cancer, to be exact—but it was sepsis that finished them both off long before the cancer seemed to be doing it. And sepsis can also hit—and kill—completely (seemingly) healthy people.
So it’s with no small excitement that I read about this:
Paul Marik, MD, chief of pulomonary and criitical care medicine at Eastern Virginia Medical School, reported in 2017 that he gave a mix of vitamin C, vitamin B1, and a steroid to nearly four dozen patients who had sepsis in his Norfolk intensive care unit. In the 7 months before he started using the treatment, 19 of 47 sepsis patients died. Of the 47 who got the treatment, all but four survived.
The results got a lot of attention. But it was a small study, comparing before-and-after patient outcomes. Now, researchers are gearing up to test the therapy with large-scale trials using patients selected at random, with some given the cocktail and others given a placebo.
“Dr. Marik feels very strongly that it’s worked in his patients, and he’s changed his practice because of his own experience,” says Jonathan Sevransky, MD, a critical care doctor at Emory University in Atlanta who is leading one of the studies. “If you think something works, it makes sense for a doctor to try something and to change their own practice. But if you want to change other people’s practices, the way to do that is do a randomized, controlled trial — and ideally, you’d have more than one randomized, controlled trial.”
It may fizzle out like so many initially promising treatments do. But it would be wonderful if it really improved the survival rates of patients with sepsis. I urge you to read this post of mine about sepsis and be aware of the signs, so that you can get help before things get to the point of no return.
Curious about Marik’s research—the article I just linked doesn’t say much—I found this. It’s a video that I can’t embed. He really gets into the meat of it at 8:20. If you listen, you can see that many of these patients were quite far gone into the sepsis process, with a prediction of 40% mortality. Their actual mortality was greatly reduced. However, the proof (or lack thereof) will be in the controlled trials:

